Hereditary angioedema-Perspective of Bangladesh
Abstract Hereditary angioedema (HAE) is a rare, potentially life-threatening genetic disorder characterized by recurrent, non-pruritic swelling of the skin, mucosa, and internal organs which is usually misdiagnosed as allergic reaction. It is due to C1-inhibitor deficiency or dysfunction and bradykinin-mediated vascular permeability. Although pathophysiology has been clarified and expanded diagnostic and therapeutic options, HAE remains unrecognized, frequently misdiagnosed, and undertreated in low- and middle-income settings. |